CELLULAR NANOINJECTION FOR BIOMEDICAL APPLICATIONS by Dr. Roey Elnathan, Deakin University, Faculty of Health, School of Medicine .Monash University, Faculty of Pharmacy and Pharmaceutical Sciences Date: 22nd October 2024 Venue: MSB 241@4pm
Abstract: Cell engineering is a major challenge for translational biomedical research. The key difficulty lies in manipulating cells to transform them without causing irreversible damage or loss of function [1]. Gaining safe, efficient, and non-destructive access to the intracellular environment of diverse cell types holds great promise for the fundamental science and application of intracellular delivery in cell engineering, with significant potential for enhancing human well-being [2,3].
The aim of the talk is to cover the development of engineering novel nanoneedle designs and fabrication paradigms—a transformative shift, allowing precise control of ex-vivo cellular processes, in particular the ability to deliver diverse cargo types via cellular
nanoinjection, bringing deep understanding of the fundamental mechanisms at the interface of nanoscale engineering and cellular
interrogation [4–6].
REFERENCES:
[1] Chiappini C*.,N.H. Voelcker* et al., Elnathan R*., Nature Protocol 2021, 16, 4539;
[2] Elnathan R*. N.H. Voelcker*et al., Nature
Nanotechnology, 2022, 17, 807;
[3] Elnathan R*., N.H. Voelcker*., et al., Nature Reviews Materials 2022, 7, 953 [4] A.-R. Shokouhi, et al.,N.H. Voelcker* .,
Elnathan R*. Advanced Materials, 2023, 35, 2304122. [5] Chen Y., et al., Elnathan R*., N.H. Voelcker*, Materials Today, 2023, 63; and [6] Acc. Chem. Res. 2024, 57, 12, 1722–1735.